Hypercholesterolemia and lipid accumulation in chondrocytes

Role of Intestinal LXRα in Regulating Post-prandial Lipid Excursion and Diet-Induced Hypercholesterolemia and Hepatic Lipid Accumulation

Post-prandial hyperlipidemia has emerged as a cardiovascular risk factor with limited therapeutic options. The Liver X receptors (Lxrs) are nuclear hormone receptors that regulate cholesterol elimination. Knowledge of their role in regulating the absorption and handling of dietary fats is incomplete. The purpose of this study was to determine the role of intestinal Lxrα in post-prandial intesti...

Growth and lipid accumulation in response to different cultivation temperatures in Nannochloropsis oculata for biodiesel production

Background: Microalgal lipid is a promising feedstock for biodiesel production. The aim of the present study was to investigate the effects of cultivation temperature on the growth and lipid accumulation properties of Nannochloropsis oculata microalgae. Methods: Nannochloropsis oculatacan grow in a wide range of temperatures (5 ~ 35°C). Late in the stationary growth phase of microalgae, bi...

Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia.

Hyperlipidemia and arterial cholesterol accumulation are primary causes of cardiovascular events. Monogenic forms of hyperlipidemia and recent genome-wide association studies indicate that genetics plays an important role. Zebrafish are a useful model for studying the genetic susceptibility to hyperlipidemia owing to conservation of many components of lipoprotein metabolism, including those rel...

preventive potential of nigella sativa l. on atherosclerosis with efficacy on lipid profile and fatty streak accumulation in diet-induced hypercholesterolemia in rabbits

Lipid-Lowering Effect of Nattokinase in Patients with Primary Hypercholesterolemia

Background: Nattokinase is a fibrinolytic enzyme isolated from the vegetable cheese natto. Although research suggests that nattokinase has beneficial effects on lipid metabolism, there is no clinical data on its effects in human patients with hypercholesterolemia. Methods: Thirty patients with primary hypercholesterolemia given instruction on a low cholesterol diet and treated with 400 mg (4000...